Enzymatic synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid using serinehydroxymethyltransferase

The scale up of earlier work from these laboratories using, the enzyme serinehydroxymethyltransferase has resulted in the use of this enzyme for the synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid (7) on a preparative scale. This compound, which has been barely described in the literature, is potentially useful for the synthesis of carbocyclic beta-lactams and carbocyclic nucleosides.