Facilitated diffusion of DNA-binding proteins

被引：61

作者：

Klenin, KV ^{[1
]}

Merlitz, H

Langowski, J

Wu, CX

机构：

[1] German Canc Res Ctr, Div Biophys Macromol, D-69120 Heidelberg, Germany

[2] Xiamen Univ, Dept Phys, Xiamen 361005, Peoples R China

来源：

PHYSICAL REVIEW LETTERS | 2006年 / 96卷 / 01期

关键词：

D O I：

10.1103/PhysRevLett.96.018104

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The diffusion-controlled limit of reaction times for site-specific DNA-binding proteins is derived from first principles. We follow the generally accepted concept that a protein propagates via two competitive modes, a three-dimensional diffusion in space and a one-dimensional sliding along the DNA. However, our theoretical treatment of the problem is new. The accuracy of our analytical model is verified by numerical simulations. The results confirm that the unspecific binding of protein to DNA, combined with sliding, is capable to reduce the reaction times significantly.

引用

页数：4

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