INNOVATION Functional immunoimaging: the revolution continues

被引：49

作者：

Bousso, Philippe ^{[1
,2
]}

Moreau, Helene D. ^{[1
,2
,3
]}

机构：

[1] Inst Pasteur, Dynam Immune Responses Unit, F-75015 Paris, France

[2] INSERM, U668, F-75015 Paris, France

[3] Univ Paris Diderot, F-75015 Paris, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 12期

基金：

欧洲研究理事会;

关键词：

DENDRITIC CELL-INTERACTIONS; IN-VIVO REVEALS; CD8(+) T-CELLS; AUTOIMMUNE CNS LESIONS; LYMPH-NODES; IMMUNOLOGICAL SYNAPSES; 2-PHOTON MICROSCOPY; B-CELLS; MYCOBACTERIAL GRANULOMAS; FLUORESCENT REPORTER;

D O I：

10.1038/nri3342

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ten years ago, in 2002, the introduction of dynamic in vivo imaging to immunologists set a new standard for studying immune responses. In particular, two-photon imaging has provided tremendous insights into immune cell dynamics in various contexts, including infection, cancer, transplantation and autoimmunity. Whereas initial studies were restricted to the migration of and interactions between immune cells, recent advances are bringing intravital imaging to a new level in which cell dynamics and function can be investigated simultaneously. These exciting developments further broaden the applications of immunoimaging and provide unprecedented opportunities to probe and decode immune cell communication in situ.

引用

收藏

页码：858 / U76

页数：7

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