Antimalarial activity and cytotoxicity of (-)-roemrefidine isolated from the stem bark of Sparattanthelium amazonum

被引：40

作者：

Muñoz, V

Sauvain, M

Mollinedo, P

Callapa, J

Rojas, I

Gimenez, A

Valentin, A

Mallié, M

机构：

[1] ORSTOM, Inst Rech Dev, F-75480 Paris 10, France

[2] Inst Boliviano Biol Altura, La Paz, Bolivia

[3] Univ Mayor San Andres, Inst Invest Farmacobioquim, La Paz, Bolivia

[4] UFR Sci Pharmaceut, Lab Immunol & Parasitol, Montpellier, France

来源：

PLANTA MEDICA | 1999年 / 65卷 / 05期

关键词：

D O I：

10.1055/s-2006-960808

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

引用

页码：448 / 449

页数：2

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