Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice

被引：31

作者：

Beckett, Karen ^{[1
]}

Franch-Marro, Xavier ^{[1
]}

Vincent, Jean-Paul ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, London NW7 1AA, England

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tcb.2008.06.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glypicans are glycosylphosphatidylinositol-linked heparan sulfate proteoglycans that play an essential part in the regulation of morphogen signalling. Two new reports using Drosophila and mice have highlighted the importance of glypican endocytosis in the regulation of Hedgehog (Hh) signalling and in Wingless gradient formation. One Drosophila glypican, Daily-like, acts positively in Hh signalling, whereas mouse Glypican-3 is a negative regulator. This difference seems to be dependent on whether glypicans promote the internalization of Hh alone or as a complex with its receptor, Patched.

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收藏

页码：360 / 363

页数：4

相关论文

共 21 条

[1] Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix [J].

Callejo, A ;

Torroja, C ;

Quijada, L ;

Guerrero, I .

DEVELOPMENT, 2006, 133 (03) :471-483

[2] Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding [J].

Capurro, Mariana I. ;

Xu, Ping ;

Shi, Wen ;

Li, Fuchuan ;

Jia, Angela ;

Filmus, Jorge .

DEVELOPMENTAL CELL, 2008, 14 (05) :700-711

[3] Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling [J].

Chiao, E ;

Fisher, P ;

Crisponi, L ;

Deiana, M ;

Dragatsis, I ;

Schlessinger, D ;

Pilia, G ;

Efstratiadis, A .

DEVELOPMENTAL BIOLOGY, 2002, 243 (01) :185-206

[4] The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila [J].

Desbordes, SC ;

Sanson, B .

DEVELOPMENT, 2003, 130 (25) :6245-6255

[5] Glypicans shunt the Wingless signal between local signalling and further transport [J].

Franch-Marro, X ;

Marchand, O ;

Piddini, E ;

Ricardo, S ;

Alexandre, C ;

Vincent, JP .

DEVELOPMENT, 2005, 132 (04) :659-666

[6] Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia [J].

Gallet, A ;

Ruel, L ;

Staccini-Lavenant, L ;

Thérond, PR .

DEVELOPMENT, 2006, 133 (03) :407-418

[7] Cellular trafficking of the glypican dally-like is required for full-strength Hedgehog signaling and Wingless transcytosis [J].

Gallet, Armel ;

Staccini-Lavenant, Laurence ;

Therond, Pascal P. .

DEVELOPMENTAL CELL, 2008, 14 (05) :712-725

[8] Communicating with Hedgehogs [J].

Hooper, JE ;

Scott, MP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :306-317

[9] Sonic hedgehog induces the segregation of patched and smoothened in endosomes [J].

Incardona, JP ;

Gruenberg, J ;

Roelink, H .

CURRENT BIOLOGY, 2002, 12 (12) :983-995

[10] Opposing activities of dally-like glypican at high and low levels of wingless morphogen activity [J].

Kreuger, J ;

Perez, L ;

Giraldez, AJ ;

Cohen, SM .

DEVELOPMENTAL CELL, 2004, 7 (04) :503-512