Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome

被引：55

作者：

Mikati, MA ^{[1
]}

Saab, R ^{[1
]}

Fayad, MN ^{[1
]}

Choueiri, RN ^{[1
]}

机构：

[1] Amer Univ Beirut, Dept Pediat, Director Adult & Pediat Epilepsy Program, New York, NY 10022 USA

来源：

PEDIATRIC NEUROLOGY | 2002年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0887-8994(01)00402-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, behavior, seizures, and electroencephalography. There was a significant drop in this score after IVIG (P = 0.025). Two patients had a dramatic response to IVIG, with complete resolution of symptoms. This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome. (C) 2002 by Elsevier Science Inc. All rights reserved.

引用

页码：298 / 300

页数：3

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