Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation

被引：38

作者：

Benedetti, F ^{[1
]}

Barbini, B ^{[1
]}

Campori, E ^{[1
]}

Colombo, C ^{[1
]}

Smeraldi, E ^{[1
]}

机构：

[1] UNIV MILAN,SCH MED,IRCCS,DEPT NEUROPSYCHIAT SCI,IST SCI,OSPED SAN RAFFAELE,I-20127 MILAN,ITALY

来源：

PSYCHIATRY RESEARCH | 1996年 / 65卷 / 03期

关键词：

affective disorder; bipolar subtype; mania; mood;

D O I：

10.1016/S0165-1781(96)03000-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed. Copyright (C) 1996 Elsevier Science Ireland Ltd.

引用

页码：179 / 184

页数：6

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