Neurodevelopmental control by thyroid hormone receptors

被引：112

作者：

Forrest, D

Reh, TA

Rüsch, A

机构：

[1] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

[2] Univ Washington, Dept Biol Struct, Hlth Sci Ctr, Seattle, WA 98195 USA

[3] Univ Tubingen, Inst Physiol, D-72076 Tubingen, Germany

[4] Univ Tubingen, Sekt Sensor Biophys, D-72076 Tubingen, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-4388(02)00289-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have provided insights into the neurodevelopmental functions of thyroid hormone signaling. The nuclear thyroid hormone receptors (TRs) are ligand-activated transcription factors and a variety of TR isotypes, generated by two genes, mediate distinct processes. In addition, deiodinase enzymes that regulate levels of the main active form of thyroid hormone, T3, are likely to cooperate closely with TRs in specifying a localized and timely response to thyroid hormones in target tissues, Some of the most sensitive processes controlled by these pathways are in the auditory and visual sensory systems.

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收藏

页码：49 / 56

页数：8

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