Vasculogenic mimicry and aberrant expression of HIF-lα/E-cad are associated with worse prognosis of esophageal squamous cell carcinoma

被引：19

作者：

Chai, Da-min ^{[1
,4
]}

Bao, Zheng-qi ^{[2
]}

Hu, Jian-guo ^{[3
]}

Ma, Li ^{[1
]}

Feng, Zhen-zhong ^{[1
]}

Tao, Yi-sheng ^{[1
]}

机构：

[1] Bengbu Med Coll, Affiliated Hosp 1, Dept Pathol, Bengbu 233000, Peoples R China

[2] Bengbu Med Coll, Affiliated Hosp 1, Dept Oncol, Bengbu 233000, Peoples R China

[3] Bengbu Med Coll, Affiliated Hosp 1, Dept Clin Lab, Bengbu 233000, Peoples R China

[4] Huazhong Univ Sci & Technol, Dept Pathophysiol, Tongji Med Coll, Wuhan 430030, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2013年 / 33卷 / 03期

基金：

中国国家自然科学基金;

关键词：

esophageal squamous cell carcinoma; vasculogenic mimicry; hypoxia inducible factor-1 alpha; E-cadherin; prognosis; CADHERIN-CATENIN COMPLEX; BETA-CATENIN; CHANNEL FORMATION; HYPOXIA; ANGIOGENESIS; LOCALIZATION; CANCER;

D O I：

10.1007/s11596-013-1129-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This study aims to find good markers for predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Vasculogenic mimicry (VM) and the expression of hypoxia inducible factor-l alpha (HIF-l alpha)/E-cad protein in ESCC were investigated by immunostaining. The association between VM, HIF-l alpha/E-cad and clinicopathologic characteristics and 5-year-survival rate of patients with ESCC was analyzed. A total of 160 ESCC specimens were involved in this study and 28 specimens of normal esophageal mucosa served as controls. VM channels were identified in 78 (48.75%) of the 160 ESCC specimens and none of the normal esophageal mucosa was found to have VM. The rates of high-expression of HIF-l alpha and E-cad in ESCC were 43.75% and 38.75%, while the rates in control were 17.86% and 71.43%, respectively (P < 0.05 for all). VM and the expression levels of HIF-l alpha and E-cad were significantly related to lymph node metastasis, serosa infiltration, PTNM staging and 5-year-survival rates of patients with ESCC (P < 0.05 for all). VM was positively correlated with HIF-l alpha but negatively with E-cad, and HIF-l alpha was negatively correlated with E-cad (P < 0.001 for all). The 5-year-survival rate of patients with ESCC was 6.41% (5/78) in VM group and 65% (52/82) in non-VM group, 7.14% (5/70) in high HIF-l alpha expression group and 57.78% (52/90) in low HIF-l alpha expression group. Oppositely, the 5-year-survival rate in high E-cad expression group was 80.65% (50/62) and that in low E-cad expression group was 7.37% (7/98) (P < 0.05 for all). Cox multifactor regression analysis indicated that lymph node metastasis, PTNM stage, VM and expression levels of HIF-l alpha and E-cad were independent risk factors of patients with ESCC (P < 0.05 for all). Combined detection of VM, HIF-l alpha and E-cad plays an important role in predicting the invasion, metastasis and prognosis of patients with ESCC.

引用

页码：385 / 391

页数：7

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