High incidence of cardiovascular disease and increased prevalence of cardiovascular risk factors in women with hypopituitarism not receiving growth hormone treatment:: preliminary results

被引:26
作者
Erfurth, EM [1 ]
Bülow, B
Eskilsson, J
Hagmar, L
机构
[1] Univ Lund Hosp, Div Endocrinol & Diabetol, Dept Internal Med, SE-22185 Lund, Sweden
[2] Univ Lund Hosp, Div Cardiol, SE-22185 Lund, Sweden
[3] Univ Lund Hosp, Div Environm & Occupat Med, SE-22185 Lund, Sweden
关键词
hypopituitarism; women; cardiovascular disease; cardiovascular risk factors;
D O I
10.1016/S1096-6374(99)80005-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Recently, epidemiological evidence has suggested that hypopituitarism with untreated growth hormone deficiency (GHD) is associated with a high incidence of cardiovascular mortality and that women are particularly at risk. In the present study, the incidence of cardiovascular disease and prevalence of cardiovascular risk factors in 33 such women was assessed and compared with matched controls. A significantly higher number of diagnosed circulatory disorders occurred in the women with hypopituitarism compared with controls, and drug consumption for cardiovascular disorders was also significantly higher in this group. Furthermore, patients with hypopituitarism had a significantly higher waist:hip ratio and a higher ratio of low-density lipoprotein to high-density lipoprotein than controls. Electrocardiogram data showed that hypopituitarism was associated with more episodes of bradycardia. In summary, women with hypopituitarism had an increased incidence of cardiovascular disease and a less favourable risk factor profile compared with matched controls. The data add support to previous studies that have shown increased risks of cardiovascular mortality associated with hypopituitarism with untreated GHD. We conclude that adequate cardiovascular surveillance programmes are required for patients with pituitary insufficiency.
引用
收藏
页码:21 / 24
页数:4
相关论文
共 7 条
[1]  
Angelin Bo, 1994, Current Opinion in Lipidology, V5, P160, DOI 10.1097/00041433-199405030-00002
[2]   The effect of hypopituitarism on life expectancy [J].
Bates, AS ;
VantHoff, W ;
Jones, PJ ;
Clayton, RN .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) :1169-1172
[3]   Increased cerebrovascular mortality in patients with hypopituitarism [J].
Bulow, B ;
Hagmar, L ;
Mikoczy, Z ;
Nordstrom, CH ;
Erfurth, EM .
CLINICAL ENDOCRINOLOGY, 1997, 46 (01) :75-81
[4]   HIGH FIBRINOGEN AND PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY IN GROWTH HORMONE-DEFICIENT ADULTS [J].
JOHANSSON, JO ;
LANDIN, K ;
TENGBORN, L ;
ROSEN, T ;
BENGTSSON, BA .
ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (03) :434-437
[5]   DETECTION OF PREMATURE ATHEROSCLEROSIS BY HIGH-RESOLUTION ULTRASONOGRAPHY IN SYMPTOM-FREE HYPOPITUITARY ADULTS [J].
MARKUSSIS, V ;
BESHYAH, SA ;
FISHER, C ;
SHARP, P ;
NICOLAIDES, AN ;
JOHNSTON, DG .
LANCET, 1992, 340 (8829) :1188-1192
[6]   CARDIOVASCULAR RISK-FACTORS IN ADULT PATIENTS WITH GROWTH-HORMONE DEFICIENCY [J].
ROSEN, T ;
EDEN, S ;
LARSON, G ;
WILHELMSEN, L ;
BENGTSSON, BA .
ACTA ENDOCRINOLOGICA, 1993, 129 (03) :195-200
[7]   PREMATURE MORTALITY DUE TO CARDIOVASCULAR-DISEASE IN HYPOPITUITARISM [J].
ROSEN, T ;
BENGTSSON, BA .
LANCET, 1990, 336 (8710) :285-288