P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia

被引：17

作者：

Paci, C

Gobbato, R

Carboni, T

Sanguigni, S

Santone, A

Curatola, L

机构：

[1] Madonna Soccorso Hosp, Neurol Unit, I-63039 San Benedetto Tronto, AP, Italy

[2] Dept Prevent, San Benedetto Tronto, AP, Italy

来源：

NEUROLOGICAL SCIENCES | 2006年 / 26卷 / 06期

关键词：

vascular dementia; P300; donepezil;

D O I：

10.1007/s10072-006-0528-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

After Alzheimer's disease (AD), vascular dementia (VaD) is the most common cause of dementia among the elderly. Abnormalities in neurotransmitter pathways are common pathogenic mechanisms shared by AD and VaD. For one month we studied the effects of donepezil, an acetylcholinesterase inhibitor (5 mg daily), on the cognitive system using P300 auditory event-related potentials (P300) and neuropsychological tests in 10 patients affected by probable VaD according to the NINDS-AIREN criteria. Our data showed a significant improvement of neuropsychological items and P300 latency after one month of donepezil treatment. In conclusion both P300 and neuropsychological tests are indicated in patients with VaD to confirm the efficacy of donepezil treatment during follow-up.

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收藏

页码：435 / 437

页数：3

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