The influence of ligand bite angle on the enantioselectivity of copper(II)-catalysed Diels-Alder reactions

被引:92
作者
Davies, IW [1 ]
Gerena, L [1 ]
Castonguay, L [1 ]
Senanayake, CH [1 ]
Larsen, RD [1 ]
Verhoeven, TR [1 ]
Reider, PJ [1 ]
机构
[1] MERCK & CO INC,DEPT MOL DESIGN & DIVERS,RAHWAY,NJ
关键词
D O I
10.1039/cc9960001753
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Novel spirobis(oxazolines) provide excellent levels of stereocontrol in copper-catalysed Diels-Alder reactions; the larger the ligand bite angle the higher the enantioselection (up to 98.4% ee).
引用
收藏
页码:1753 / 1754
页数:2
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