Emergence of inflammatory bowel disease 'beyond the West': do prosperity and improved hygiene have a role?

被引：19

作者：

de Silva, H. J. ^{[1
]}

de Silva, N. R. ^{[2
]}

de Silva, A. P. ^{[1
]}

Jewell, D. P. ^{[3
]}

机构：

[1] Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka

[2] Univ Kelaniya, Fac Med, Dept Parasitol, Ragama, Sri Lanka

[3] John Radcliffe Hosp, Gastroenterol Unit, Oxford OX3 9DU, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 09期

关键词：

inflammatory bowel disease; hygiene; helminth infection; incidence; economic development; developing countries;

D O I：

10.1016/j.trstmh.2008.03.016

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Inflammatory bowel disease (I BD) is increasing in many countries 'beyond the West'. This increase may be due to an increased rate of diagnosis but might also represent a true increase in incidence. Economic development, leading to improved hygiene and other changes in lifestyle, may play a role in the increase in IBD. However, the marked difference in prevalence between ethnic groups suggests that the genetic background of populations may also be relevant and supports the current hypothesis that IBD represents an interaction between environmental factors and a genetically susceptible host. Investigating the early stages of IBD as it emerges in new populations may provide new clues to its pathophysiology. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：857 / 860

页数：4

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