Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.

被引：59

作者：

Naisbitt, DJ ^{[1
]}

ONeill, PM ^{[1
]}

Pirmohamed, M ^{[1
]}

Park, BK ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT THERAPEUT & PHARMACOL,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00260-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulphamethoxazole hydroxylamine (SMX-NHOH) and nitroso sulphamethoxazole (SMX-NO) were prepared by a modified literature procedure. SMX-NO produced a complex set of unstable intermediates with sulphur nucleophiles, but did not react with amino containing compounds. No reactions were observed between sulphamethoxazole (SMX)/SMX-NHOH and the nucleophiles used in this study. Thus antigens formed from N-oxidation of SMX are likely to be unstable in vivo. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1511 / 1516

页数：6

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