Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products

被引：38

作者：

Herderich, M ^{[1
]}

Richling, E ^{[1
]}

Roscher, R ^{[1
]}

Schneider, C ^{[1
]}

Schwab, W ^{[1
]}

Humpf, HU ^{[1
]}

Schreier, P ^{[1
]}

机构：

[1] UNIV WURZBURG, LEHRSTUHL LEBENSMITTELCHEM, D-97074 WURZBURG, GERMANY

来源：

CHROMATOGRAPHIA | 1997年 / 45卷 / 1期

关键词：

column liquid chromatography; tandem mass spectrometry (MS-MS); electrospray ionization (ESI); atmospheric pressure chemical ionization (APCI); selected reaction monitoring (SRM); natural products;

D O I：

10.1007/BF02505549

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of techniques utilizing atmospheric pressure ionization, namely atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI), has pioneered the coupling of liquid chromatography (HPLC) with mass spectrometry in recent years. Both ESI and APCI generate ions from polar and labile biomaterials with remarkable ease and efficiency. In particular, the use of HPLC with tandem mass spectrometry (MS-MS) opens further dimensions in the field of bioorganic analysis. Thus, HPLC-MS-MS provides the tools for direct elucidation of the structure and variety of polar natural compounds in complex matrices. In order to develop efficient and straightforward strategies for the analysis of polar natural products, the potential and the limitations of these hyphenated analytical techniques are discussed using heterocyclic aromatic amines, fumonisins, acylated glycoconjugates and regioisomeric fatty acid hydroperoxides as examples.

引用

页码：127 / 132

页数：6

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