A microfluidic abacus channel for controlling the addition of droplets

被引：23

作者：

Um, Eujin ^{[1
]}

Park, Je-Kyun ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Sci Biol, Taejon 305701, South Korea

来源：

LAB ON A CHIP | 2009年 / 9卷 / 02期

关键词：

GENERATION;

D O I：

10.1039/b814948h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports the first use of the abacus-groove structure to handle droplets in a wide microchannel, with no external forces integrated to the system other than the pumps. Microfluidic abacus channels are demonstrated for the sequential addition of droplets at the desired location. A control channel which is analogous to biasing in electronics can also be used to precisely determine the number of added droplets, when all other experimental conditions are fixed including the size of the droplets and the frequency of droplet-generation. The device allows programmable and autonomous operations of complex two-phase microfluidics as well as new applications for the method of analysis and computations in lab-on-a-chip devices.

引用

页码：207 / 212

页数：6

共 30 条

[1] Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels [J].

Ahn, Keunho ;

Agresti, Jeremy ;

Chong, Henry ;

Marquez, Manuel ;

Weitz, D. A. .

APPLIED PHYSICS LETTERS, 2006, 88 (26)

[2] Formation of dispersions using "flow focusing" in microchannels [J].

Anna, SL ;

Bontoux, N ;

Stone, HA .

APPLIED PHYSICS LETTERS, 2003, 82 (03) :364-366

[3] An optical toolbox for total control of droplet microfluidics [J].

Baroud, Charles N. ;

de Saint Vincent, Matthieu Robert ;

Delville, Jean-Pierre .

LAB ON A CHIP, 2007, 7 (08) :1029-1033

[4] Decompressing emulsion droplets favors coalescence [J].

Bremond, Nicolas ;

Thiam, Abdou R. ;

Bibette, Jerome .

PHYSICAL REVIEW LETTERS, 2008, 100 (02)

[5] Generation of dynamic chemical signals with microfluidic C-DACs [J].

Chen, L. ;

Azizi, F. ;

Mastrangelo, C. H. .

LAB ON A CHIP, 2007, 7 (07) :850-855

[6] Digital microfluidics: Droplet based logic gates [J].

Cheow, Lih Feng ;

Yobas, Levent ;

Kwong, Dim-Lee .

APPLIED PHYSICS LETTERS, 2007, 90 (05)

[7] Guided and fluidic self-assembly of microstructures using railed microfluidic channels [J].

Chung, Su Eun ;

Park, Wook ;

Shin, Sunghwan ;

Lee, Seung Ah ;

Kwon, Sunghoon .

NATURE MATERIALS, 2008, 7 (07) :581-587

[8] Lab-on-a-chip: microfluidics in drug discovery [J].

Dittrich, PS ;

Manz, A .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :210-218

[9] Can droplets and bubbles think? [J].

Epstein, Irving R. .

SCIENCE, 2007, 315 (5813) :775-776

[10] Coding/decoding and reversibility of droplet trains in microfluidic networks [J].

Fuerstman, Michael J. ;

Garstecki, Piotr ;

Whitesides, George M. .

SCIENCE, 2007, 315 (5813) :828-832

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