共 54 条
Primate evolution of an olfactory receptor cluster: Diversification by gene conversion and recent emergence of pseudogenes
被引:96
作者:

Sharon, D
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Glusman, G
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Pilpel, Y
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Khen, M
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Gruetzner, F
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Haaf, T
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h-index: 0
机构: Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

Lancet, D
论文数: 0 引用数: 0
h-index: 0
机构:
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
机构:
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
[2] Weizmann Inst Sci, Crown Human Genome Ctr, IL-76100 Rehovot, Israel
[3] Max Planck Inst Mol Genet, D-14195 Berlin, Germany
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D O I:
10.1006/geno.1999.5900
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
The olfactory receptor (OR) subgenome harbors the largest known gene family in mammals, disposed in clusters on numerous chromosomes. We have carried out a comparative evolutionary analysis of the best characterized genomic OR gene cluster, on human chromosome 17p13. Fifteen orthologs from chimpanzee (localized to chromosome 19p15), as well as key OR counterparts from other primates, have been identified and sequenced. Comparison among orthologs and paralogs revealed a multiplicity of gene conversion events, which occurred exclusively within OR subfamilies. These appear to lead to segment shuffling in the odorant binding site, an evolutionary process reminiscent of somatic combinatorial diversification in the immune system We also demonstrate that the functional mammalian OR repertoire has undergone a rapid decline in the past 10 million years: while for the common ancestor of all great apes an intact OR cluster is inferred, in present-day humans and great apes the cluster includes nearly 40% pseudogenes. (C) 1999 Academic Press.
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页码:24 / 36
页数:13
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