Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy

被引：42

作者：

Roberts, Susanne M.

Freeman, Alexandra F.

Harrington, Susan M.

Holland, Steven M.

Murray, Patrick R.

Zelazny, Adrian M.

机构：

[1] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA

[2] NIAID, NIH, US Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2006年 / 25卷 / 06期

关键词：

linezolid resistance; Staphylococcus aureus; hyper-IgE syndrome;

D O I：

10.1097/01.inf.0000219401.70804.1a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report 2 sisters with hyper-IgE syndrome treated with daily suppressive dosages of linezolid (LZD) who developed LZD-resistant Staphylococcus aureus carrying the G2576T mutation in the 23S rRNA gene. Molecular typing suggested transmission of the resistant strain from one sister to the other. LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy.

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收藏

页码：562 / 564

页数：3

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