Solution and solid-phase synthesis of trifluoromethyl peptides and mimetics

被引：12

作者：

Bravo, P

Bruché, L

Pesenti, C

Viani, F

Volonterio, A

Zanda, M

机构：

[1] Politecn Milan, Dipartimento Chim, I-20131 Milan, Italy

[2] CNR, Ctr Studio Sostanze Organ Nat, I-20131 Milan, Italy

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 112卷 / 01期

关键词：

D O I：

10.1016/S0022-1139(01)00485-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper reviews the solution-phase synthesis of trifluoromethyl (Tfm)-analogues of bioactive peptides, such as RGD-peptides and the aspartyl protease inhibitor pepstatin, and the solution/solid-phase synthesis of Tfm-substituted retro- and retro-inverso peptides and hydroxamates. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：153 / 162

页数：10

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