Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium

被引：46

作者：

Muschietti, L

Gorzalczany, S

Ferraro, G

Acevedo, C

Martino, V

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacognosia, IQUIMEFA,CONICET, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacol, RA-1113 Buenos Aires, DF, Argentina

来源：

PLANTA MEDICA | 2001年 / 67卷 / 08期

关键词：

D O I：

10.1055/s-2001-18355

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-inflammatory activity was detected in the CH2Cl2 extract of the aerial parts of Eupatorium buniifolium using the TPA-mouse ear model. Three compounds isolated from this extract, by bioassay-guided fractionation, significantly inhibited the inflammatory response. The compounds were identified as 5,7,5'-trihydroxy-3,6,2',4'-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, respectively, at a dose of 1 mg/ear.

引用

页码：743 / 744

页数：2

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