Inputs and outputs for chromatin-targeted RNAi

被引：26

作者：

Chan, Simon W-L. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Plant Biol, Davis, CA 95616 USA

来源：

TRENDS IN PLANT SCIENCE | 2008年 / 13卷 / 07期

关键词：

D O I：

10.1016/j.tplants.2008.05.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plant gene silencing is targeted to transposons and repeated sequences by small RNAs from the RNA interference (RNAi) pathway. Like classical RNAi, RNA-directed chromatin silencing involves the cleavage of double-stranded RNA by Dicer endonucleases to create small interfering RNAs (siRNAs), which bind to the Argonaute protein. The production of double-stranded RNA (dsRNA) must be carefully controlled to prevent inappropriate silencing. A plant-specific RNA polymerase IV (Pol IV) initiates siRNA production at silent heterochromatin, but Pol IV-independent mechanisms for making dsRNA also exist. Downstream of siRNA biogenesis, multiple chromatin marks might be targeted by Argonaute-siRNA complexes, yet mechanisms of chromatin modification remain poorly understood. Genomic studies of siRNA target loci promise to reveal novel biological functions for chromatin-targeted RNAi.

引用

页码：383 / 389

页数：7

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