In and out: histone variant exchange in chromatin

被引：121

作者：

Jin, JJ ^{[1
]}

Cai, Y ^{[1
]}

Li, B ^{[1
]}

Conaway, RC ^{[1
]}

Workman, JL ^{[1
]}

Conaway, JW ^{[1
]}

Kusch, T ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 12期

关键词：

D O I：

10.1016/j.tibs.2005.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes. In contrast to the canonical histones, which are deposited behind the replication fork during S phase, histone variants are incorporated in a process that is independent of DNA replication. Recent studies have shown that distinct multiprotein complexes are responsible for the targeted deposition of histone variants at active genes, centromeres and silent loci. The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.

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页码：680 / 687

页数：8

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