The tangled path to glucose production

被引：19

作者：

Matsumoto, M ^{[1
]}

Accili, D ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 01期

关键词：

D O I：

10.1038/nm0106-33

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver glucose production is crucial to survival during fast and is abnormally elevated in diabetes. Studies of the transcriptional coactivator Torc2 redefine the mechanism by which cAMP signaling affects fasting-induced glucogenesis.

引用

页码：33 / 34

页数：3

共 13 条

[1] PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP [J].

CHRIVIA, JC ;

KWOK, RPS ;

LAMB, N ;

HAGIWARA, M ;

MONTMINY, MR ;

GOODMAN, RH .

NATURE, 1993, 365 (6449) :855-859

[2]

EXTON JH, 1968, J BIOL CHEM, V243, P4189

[3] INHIBITION OF TRANSCRIPTION OF THE PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE BY INSULIN [J].

GRANNER, D ;

ANDREONE, T ;

SASAKI, K ;

BEALE, E .

NATURE, 1983, 305 (5934) :549-551

[4] THE ORPHAN RECEPTORS COUP-TF AND HNF-4 SERVE AS ACCESSORY FACTORS REQUIRED FOR INDUCTION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE-TRANSCRIPTION BY GLUCOCORTICOIDS [J].

HALL, RK ;

SLADEK, FM ;

GRANNER, DK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :412-416

[5] CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ [J].

Herzig, S ;

Hedrick, S ;

Morantte, I ;

Koo, SH ;

Galimi, F ;

Montminy, M .

NATURE, 2003, 426 (6963) :190-193

[6] The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism [J].

Koo, SH ;

Flechner, L ;

Qi, L ;

Zhang, XM ;

Screaton, RA ;

Jeffries, S ;

Hedrick, S ;

Xu, W ;

Boussouar, F ;

Brindle, P ;

Takemori, H ;

Montminy, M .

NATURE, 2005, 437 (7062) :1109-1114

[7] The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression [J].

Nakae, J ;

Kitamura, T ;

Silver, DL ;

Accili, D .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1359-1367

[8] Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction [J].

Puigserver, P ;

Rhee, J ;

Donovan, J ;

Walkey, CJ ;

Yoon, JC ;

Oriente, F ;

Kitamura, Y ;

Altomonte, J ;

Dong, HJ ;

Accili, D ;

Spiegelman, BM .

NATURE, 2003, 423 (6939) :550-555

[9]

SASAKI K, 1984, J BIOL CHEM, V259, P5242

[10] IMPAIRED ENERGY HOMEOSTASIS IN C/EBP-ALPHA KNOCKOUT MICE [J].

WANG, ND ;

FINEGOLD, MJ ;

BRADLEY, A ;

OU, CN ;

ABDELSAYED, SV ;

WILDE, MD ;

TAYLOR, LR ;

WILSON, DR ;

DARLINGTON, GJ .

SCIENCE, 1995, 269 (5227) :1108-1112

← 1 2 →