Glucagon-like peptide 2

被引：43

作者：

Drucker, DJ ^{[1
]}

机构：

[1] Univ Toronto, Toronto Hosp, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1043-2760(98)00136-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide 2 (GLP-2) is secreted in a nutrient-dependent manner from enteroendocrine cells throughout the gastrointestinal tract and is trophic to the intestinal epithelial mucosa. GLP-2 acts via stimulation of crypt cell proliferation and inhibition of cell death. GLP-2 also stimulates intestinal glucose transport, decreases mucosal permeability, and shows therapeutic efficacy in experimental models of short bowel syndrome and both small and large bowel inflammation.

引用

页码：153 / 156

页数：4

共 25 条

[1] Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2
Brubaker, PL
Crivici, A
Izzo, N
Ehrlich, P
Tsai, CH
Drucker, DJ
[J]. ENDOCRINOLOGY, 1997, 138 (11) : 4837 - 4843
[2] Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2
Brubaker, PL
Izzo, A
Hill, M
Drucker, DJ
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 272 (06): : E1050 - E1058
[3] Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2
Chance, WT
FoleyNelson, T
Thomas, I
Balasubramaniam, A
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 273 (02): : G559 - G563
[4] The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport
Cheeseman, CI
Tsang, R
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1996, 271 (03): : G477 - G482
[5] Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
Cheeseman, CI
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 273 (06) : R1965 - R1971
[6] Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2
Drucker, DJ
DeForest, L
Brubaker, PL
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 273 (06): : G1252 - G1262
[7] Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis
Drucker, DJ
Yusta, B
Boushey, RP
DeForest, L
Brubaker, PL
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1999, 276 (01): : G79 - G91
[8] Glucagon-like peptides
Drucker, DJ
[J]. DIABETES, 1998, 47 (02) : 159 - 169
[9] Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV
Drucker, DJ
Shi, Q
Crivici, A
SumnerSmith, M
Tavares, W
Hill, M
DeForest, L
Cooper, S
Brubaker, PL
[J]. NATURE BIOTECHNOLOGY, 1997, 15 (07) : 673 - 677
[10] Induction of intestinal epithelial proliferation by glucagon-like peptide 2
Drucker, DJ
Ehrlich, P
Asa, SL
Brubaker, PL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) : 7911 - 7916

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