L-purine nucleosides as selective antimalarials

被引：11

作者：

Gero, AM ^{[1
]}

Perrone, G

Brown, DM

Hall, ST

Chu, CK

机构：

[1] Univ New S Wales, Sch Biochem & Mol Genet, Sydney, NSW 2052, Australia

[2] Univ Georgia, Coll Pharm, Athens, GA 30602 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041593

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.

引用

页码：885 / 889

页数：5

共 9 条

[1] ADENOSINE DEAMINASE FROM HUMAN ERYTHROCYTES - PURIFICATION AND EFFECTS OF ADENOSINE-ANALOGS [J].

AGARWAL, RP ;

SAGAR, SM ;

PARKS, RE .

BIOCHEMICAL PHARMACOLOGY, 1975, 24 (06) :693-701

[2] INDUCTION OF NUCLEOSIDE TRANSPORT SITES INTO THE HOST-CELL MEMBRANE OF BABESIA-BOVIS INFECTED ERYTHROCYTES [J].

GERO, AM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 35 (03) :269-276

[3] Plasmodium falciparum: Transport of entantiomers of nucleosides into Sendai-treated trophozoites [J].

Gero, AM ;

Hall, ST .

EXPERIMENTAL PARASITOLOGY, 1997, 86 (03) :228-231

[4] ANTIMALARIAL ACTION OF NITROBENZYLTHIOINOSINE IN COMBINATION WITH PURINE NUCLEOSIDE ANTIMETABOLITES [J].

GERO, AM ;

SCOTT, HV ;

OSULLIVAN, WJ ;

CHRISTOPHERSON, RI .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 34 (01) :87-97

[5] ALTERED MEMBRANE-PERMEABILITY - A NEW APPROACH TO MALARIA CHEMOTHERAPY [J].

GERO, AM ;

UPSTON, JM .

PARASITOLOGY TODAY, 1992, 8 (08) :283-286

[6] NUCLEOSIDE ANALOGS AS CHEMOTHERAPEUTIC-AGENTS - A REVIEW [J].

PERIGAUD, C ;

GOSSELIN, G ;

IMBACH, JL .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1992, 11 (2-4) :903-945

[7] ENZYMES OF PURINE AND PYRIMIDINE METABOLISM FROM THE HUMAN MALARIA, PLASMODIUM-FALCIPARUM [J].

REYES, P ;

RATHOD, PK ;

SANCHEZ, DJ ;

MREMA, JEK ;

RIECKMANN, KH ;

HEIDRICH, HG .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1982, 5 (05) :275-290

[8] PARASITE-INDUCED PERMEATION OF NUCLEOSIDES IN PLASMODIUM-FALCIPARUM MALARIA [J].

UPSTON, JM ;

GERO, AM .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1236 (02) :249-258

[9] Inhibition of Epstein-Barr virus replication by a novel L-nucleoside,2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil [J].

Yao, GQ ;

Liu, SH ;

Chou, E ;

Kukhanova, M ;

Chu, CK ;

Cheng, YC .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (07) :941-947

← 1 →