Mass spectrometric separation and determination of N1, N12-diacetylspermine in the urine of cancer patients

被引：12

作者：

Kobayashi, M

Samejima, K

Hiramatsu, K

Kawakita, M

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Sakado, Saitama 3500290, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Physiol Chem, Bunkyo Ku, Tokyo 1138613, Japan

[3] Kogakuin Univ, Dept Appl Chem, Shinjuku Ku, Tokyo 1638677, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 03期

关键词：

diacetylspermine; IS-MS; N-15-polyamine; biomarker; cancer; analysis of urine;

D O I：

10.1248/bpb.25.372

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

An ionspray ionization mass-spectrometric method for the determination of N-1,N-12-diacetylspermine (Ac(2)Spm) was developed using N-15-labeled Ac(2)Spm as the internal standard. Concentrations of Ac(2)Spm in the urine obtained from 17 cancer patients measured by the present method correlated well with those measured by ELISA, showing the usefulness of the two methods.

引用

页码：372 / 374

页数：3

共 11 条

[1]

Bachrach U, 1992, Prog Drug Res, V39, P9

[2]

Ionspray ionization mass spectrometric separation and determination of heptafluorobutyryl derivatives of polyamines [J].