p75(NTR) and apoptosis: Trk-dependent and Trk-independent effects

被引：164

作者：

Bredesen, DE

Rabizadeh, S

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093

[2] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,INTERDEPARTMENTAL PROGRAM NEUROSCI,LOS ANGELES,CA 90024

来源：

TRENDS IN NEUROSCIENCES | 1997年 / 20卷 / 07期

关键词：

D O I：

10.1016/S0166-2236(96)01049-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ongoing dissection of the roles of p75(NTR) and TrkA, -B and -C in neurotrophin signaling has generated a number of apparent paradoxes. Limiting consideration to the role of p75(NTR) in cell death, a theory is proposed that is based on the following postulates: (I) that p75(NTR) displays a pro-apoptotic intrinsic (ligand-independent,Trk-independent) receptor effect (IRE), which is inhibited by ligand binding;(2) that p75(NTR) and TrkA exhibit mutual repression of signaling; and (3) that p75(NTR) and TrkA are required for the efficient generation of high-affinity NGF binding sites.

引用

页码：287 / 290

页数：4

共 37 条

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