β2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics

被引：60

作者：

Kotani, Y ^{[1
]}

Nishimura, Y ^{[1
]}

Maeda, H ^{[1
]}

Yokoyama, M ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 1, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

JOURNAL OF ASTHMA | 1999年 / 36卷 / 07期

关键词：

bronchial asthma; beta(2)-adrenergic receptor gene; onset; airway responsiveness;

D O I：

10.3109/02770909909087295

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We examined the beta(2)-adrenergic receptor (beta(2)AR) polymorphisms (Arg16 --> Gly, Gln27 --> Glu) and clinical status for 117 asthmatics. Airway responsiveness to methacholine and beta(2)-agonists was evaluated with Astograph(R). The atopic factors, pulmonary function test, and airway responsiveness to methacholine did not differ significantly among the different beta(2)AR genotypes. Asthmatics homozygous for Gly16 showed significantly lower airway responsiveness to inhaled salbutamol than those heterozygous for Arg/Gly16 or homozygous for Arg16. Asthmatics heterozygous for Gln/Glu27 had significantly later asthma onsets than those homozygous for Gln27. These results suggest that beta(2)AR poly morphisms play an important role in the airway responsiveness to inhaled beta(2)-agonist and the initial asthma onset.

引用

页码：583 / 590

页数：8

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