The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene

被引：25

作者：

Du Plessis, J ^{[1
]}

Pugh, WJ

Judefeind, A

Hadgraft, J

机构：

[1] Potchefstroom Univ Christian Higher Educ, Sch Pharm, ZA-2520 Potchefstroom, South Africa

[2] Cardiff Univ, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[3] Univ Greenwich, NRI, Chatham ME4 4TB, Kent, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2002年 / 15卷 / 01期

基金：

英国惠康基金;

关键词：

hydrogen bonding; silicone; skin; phenols; diffusion; thermodynamic activity; solvatochromic effects;

D O I：

10.1016/S0928-0987(01)00212-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The permeation of a series of structurally related compounds across silicone membranes (PDMS) was studied. The PDMS was saturated either with toluene, to mimic a functionally inert barrier, or octanol, to mimic the polar/hydrogen bonding environment of the stratum corneum lipid barrier. Phenol, salicylic acid, benzoic acid, anisole, phenylethanol and benzyl alcohol were chosen in an attempt to relate permeation to their different H-bonding capabilities. The flux was lower through the octanol system suggesting retardation by polar/H-bonding interactions. Separation of the permeability coefficient into its thermodynamic (partition coefficient) and kinetic (diffusion coefficient) terms suggests that the effect of altering polarity within the membrane has a greater impact on the diffusion of permeant rather than its chemical potential within the membrane. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：63 / 69

页数：7

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