Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV

被引：118

作者：

Brierley, Ian

Dos Ramos, Francisco J.

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[2] Univ Cambridge, Dept Med, Cambridge CB2 2QQ, England

来源：

VIRUS RESEARCH | 2006年 / 119卷 / 01期

关键词：

ribosomal frameshifting; HIV-1; retrovirus; SARS-CoV; coronavirus; RNA pseudoknot; translation;

D O I：

10.1016/j.virusres.2005.10.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type I (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS-CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshiffing in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed. (c) 2005 Elsevier B.V. All rights reserved.

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页码：29 / 42

页数：14

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