Oral Plus Nasal Corticosteroids Improve Smell, Nasal Congestion, and Inflammation in Sino-Nasal Polyposis

Objectives/HypothesisTo assess the effect of oral plus intranasal corticosteroids on subjective outcomes (smell and nasal congestion) and objective outcomes (tissue eosinophilia and nitric oxide) in severe nasal polyposis (NP). Study DesignAfter a 4-week steroid washout period (w0), severe NP were randomized into a treatment group (n=67) that receive oral prednisone for 2 weeks (w2) plus intranasal budesonide for 12 weeks (w12), and a control group (n=22) that received no steroid treatment. MethodsBarcelona Smell Test 24 (BAST-24), nasal congestion, tissue eosinophilia, and nasal nitric oxide (nNO) were assessed. ResultsBefore treatment, patients showed a significant impairment of smell detection (30.739.5%), identification (7.116.1%), and forced choice (13.8 +/- 23.3%) in BAST-24 compared to healthy population. At w2, the treatment group showed a significant improvement in detection, identification, and forced choice. Positive effect was also seen after 12 weeks of intranasal corticosteroids. A significant reduction of nasal congestion (1.17 +/- 1.0 vs. 2.73 +/- 0.5) and polyp tissue eosinophilia (10.9 +/- 4.2 vs. 41.2 +/- 12.2) with an increase of nNO (650 +/- 317 vs. 420 +/- 221 ppb) were observed at w2 compared to w0 and to the control group. These effects were also seen at w12. ConclusionsCombined oral and intranasal corticosteroids improve smell and nasal congestion and decrease nasal inflammation, as measured by reduced tissue eosinophilia and increased detection of nNO. Severity of smell loss correlates with degree of nasal congestion but not with inflammation, as measured by tissue eosinophilia or nasally exhaled nNO. Our findings suggest that improvement in smell may be related to improved conduction of odorants to the olfactory neuroepithelium.