Analysing competing risks data with transformation models

被引:52
作者
Fine, JP
机构
[1] Univ Wisconsin, Dept Stat, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53792 USA
关键词
cumulative incidence function; generalized odds rate model; martingale; U-statistic;
D O I
10.1111/1467-9868.00204
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We present a flexible class of marginal models for the cumulative incidence function. The semiparametric transformation model is utilized in a decomposition for the marginal failure probabilities which extends previous work on Farewell's cure model. Novel estimation, inference and prediction procedures are developed, with large sample properties derived from the theory of martingales and U-statistics. A small simulation study demonstrates that the methods are appropriate far practical use. The methods are illustrated with a thorough analysis of a prostate cancer clinical trial. Simple graphical displays are used to check for the goodness of fit.
引用
收藏
页码:817 / 830
页数:14
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