Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

被引:388
作者
Wang, JJ
Rao, HY
Wetmore, GS
Furlan, PM
Korczykowski, M
Dinges, DF
Detre, JA
机构
[1] Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
[5] Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA
关键词
anterior cingulate cortex; arterial spin labeling; right prefrontal cortex;
D O I
10.1073/pnas.0503082102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Despite the prevalence of stress in everyday life and its impact on happiness, health, and cognition, little is known about the neural substrate of the experience of everyday stress in humans. We use a quantitative and noninvasive neuroimaging technique, arterial spin-labeling perfusion MRI, to measure cerebral blood flow (CBF) changes associated with mild to moderate stress induced by a mental arithmetic task with performance monitoring. Elicitation of stress was verified by self-report of stress and emotional state and measures of heart rate and salivary-cortisol level. The change in CBF induced by the stress task was positively correlated with subjective stress rating in the ventral right prefrontal cortex (RPFC) and left insula/putamen area. The ventral RPFC along with right insula/putamen and anterior cingulate showed sustained activation after task completion in subjects reporting a high stress level during arithmetic tasks. Additionally, variations of baseline CBF in the ventral RPFC and right orbitofrontal cortex were found to correlate with changes in salivary-cortisol level and heart rate caused by undergoing stress tasks. We further demonstrated that the observed right prefrontal activation could not be attributed to increased cognitive demand accompanying stress tasks and extended beyond neural pathways associated with negative emotions. Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.
引用
收藏
页码:17804 / 17809
页数:6
相关论文
共 49 条
[1]   Experimental design and the relative sensitivity of BOLD and perfusion fMRI [J].
Aguirre, GK ;
Detre, JA ;
Zarahn, E ;
Alsop, DC .
NEUROIMAGE, 2002, 15 (03) :488-500
[2]   A mechanism converting psychosocial stress into mononuclear cell activation [J].
Bierhaus, A ;
Wolf, J ;
Andrassy, M ;
Rohleder, N ;
Humpert, PM ;
Petrov, D ;
Ferstl, R ;
von Eynatten, M ;
Wendt, T ;
Rudofsky, G ;
Joswig, M ;
Morcos, M ;
Schwaninger, M ;
McEwen, B ;
Kirschbaum, C ;
Nawroth, PP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1920-1925
[3]   Resting regional cerebral perfusion in recent posttraumatic stress disorder [J].
Bonne, O ;
Gilboa, A ;
Louzoun, Y ;
Brandes, D ;
Yona, I ;
Lester, H ;
Barkai, G ;
Freedman, N ;
Chisin, R ;
Shalev, AY .
BIOLOGICAL PSYCHIATRY, 2003, 54 (10) :1077-1086
[4]   Impaired recognition and experience of disgust following brain injury [J].
Calder, AJ ;
Keane, J ;
Manes, F ;
Antoun, N ;
Young, AW .
NATURE NEUROSCIENCE, 2000, 3 (11) :1077-1078
[5]   Neuroendocrine pharmacology of stress [J].
Carrasco, GA ;
de Kar, LDV .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 463 (1-3) :235-272
[6]   Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].
Caspi, A ;
Sugden, K ;
Moffitt, TE ;
Taylor, A ;
Craig, IW ;
Harrington, H ;
McClay, J ;
Mill, J ;
Martin, J ;
Braithwaite, A ;
Poulton, R .
SCIENCE, 2003, 301 (5631) :386-389
[7]   Psychobiological and vulnerability : Implications for successful adaptation to extreme stress [J].
Charney, DS .
AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (02) :195-216
[8]   Frontal EEG asymmetry as a moderator and mediator of emotion [J].
Coan, JA ;
Allen, JJB .
BIOLOGICAL PSYCHOLOGY, 2004, 67 (1-2) :7-49
[9]   NEGATIVE LIFE EVENTS, PERCEIVED STRESS, NEGATIVE AFFECT, AND SUSCEPTIBILITY TO THE COMMON COLD [J].
COHEN, S ;
TYRRELL, DAJ ;
SMITH, AP .
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1993, 64 (01) :131-140
[10]  
Davidson RJ, 2000, PSYCHOL BULL, V126, P890, DOI [10.1037//0033-2909.126.6.890, 10.1037/0033-2909.126.6.890]