Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-β1

被引：22

作者：

Fletcher, Helen A. ^{[1
]}

Pathan, Ansar A. ^{[1
]}

Berthoud, Tamara K. ^{[1
]}

Dunachie, Susanna J. ^{[1
]}

Whelan, Kathryn T. ^{[1
]}

Alder, Nicola C. ^{[2
]}

Sander, Clare R. ^{[1
]}

Hill, Adrian V. S. ^{[1
]}

McShane, Helen ^{[1
]}

机构：

[1] Univ Oxford, Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

[2] Univ Oxford, Wolfson Coll, Ctr Stat Med, Oxford OX2 6UD, England

来源：

VACCINE | 2008年 / 26卷 / 41期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

TGF-beta; 1; Regulatory T cells; Tuberculosis;

D O I：

10.1016/j.vaccine.2008.07.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming growth factor beta 1 (TGF-beta 1) mRNA in peripheral blood lymphocytes and reduces TGF-beta 1 protein in the serum, but increases IFN-gamma ELISPOT responses to the recall antigen SK/SD. TGF-beta 1 is essential for the generation of regulatory T cells and we see a correlation across vaccinees between CD4+CD25hiFoxP3+ cells and TGF-beta 1 serum levels. This apparent ability to counteract regulatory T cell effects suggests a potential use of MVA85A as an adjuvant for less immunogenic vaccines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5269 / 5275

页数：7

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