Phylogenetic Reconstruction of Transmission Events from Individuals with Acute HIV Infection: Toward More-Rigorous Epidemiological Definitions

被引：35

作者：

Brown, Alison E. ^{[1
,4
]}

Gifford, Robert J. ^{[2
]}

Clewley, Jonathan P. ^{[1
]}

Kucherer, Claudia ^{[5
]}

Masquelier, Bernard ^{[6
]}

Porter, Kholoud ^{[3
]}

Balotta, Claudia ^{[7
]}

Back, Nicole K. T. ^{[8
]}

Jorgensen, Louise Bruun ^{[9
]}

de Mendoza, Carmen ^{[10
]}

Bhaskaran, Krishnan ^{[3
]}

Gill, O. Noel ^{[1
]}

Johnson, Anne M. ^{[4
]}

Pillay, Deenan ^{[1
,2
]}

机构：

[1] Hlth Protect Agcy, Ctr Infect, HIV STI Dept, London NW9 5EQ, England

[2] UCL, Ctr Virol, London, England

[3] UCL, Med Res Council Clin Trials, London, England

[4] UCL, Div Populat Hlth, London, England

[5] Robert Koch Inst, D-1000 Berlin, Germany

[6] Ctr Hosp Univ, Dept Virol & Immunol Biol, Bordeaux, France

[7] Univ Milan, Inst Infect & Trop Dis, Milan, Italy

[8] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[9] Statens Serum Inst, DK-2300 Copenhagen, Denmark

[10] Hosp Carlos III, Infect Dis Serv, Madrid, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 03期

基金：

英国医学研究理事会;

关键词：

DRUG-RESISTANCE; MUTATIONS; THERAPY;

D O I：

10.1086/596049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

引用

页码：427 / 431

页数：5

共 14 条

[1]

High rates of forward transmission events after acute/early HIV-1 infection [J].

Brenner, Bluma G. ;

Roger, Michel ;

Routy, Jean-Pierre ;

Moisi, Daniela ;

Ntemgwa, Michel ;

Matte, Claudine ;

Baril, Jean-Guy ;

Thomas, Rejean ;

Rouleau, Danielle ;

Bruneau, Julie ;

Leblanc, Roger ;

Legault, Mario ;

Tremblay, Cecile ;

Charest, Hugues ;

Wainberg, Mark A. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (07) :951-959

[2]

Devereux HL, 1999, AIDS, V13, pF123, DOI 10.1097/00002030-199912240-00001

[3]

Rapid, real-time detection of acute HIV infection in patients in Africa [J].

Fiscus, Susan A. ;

Pilcher, Christopher D. ;

Miller, William C. ;

Powers, Kimberly A. ;

Hoffman, Irving F. ;

Price, Matthew ;

Chilongozi, David A. ;

Mapanje, Clement ;

Krysiak, Robert ;

Gama, Syze ;

Martinson, Francis E. A. ;

Cohen, Myron S. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (03) :416-424

[4]

Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda [J].

Gray, RH ;

Wawer, MJ ;

Brookmeyer, R ;

Sewankambo, NK ;

Serwadda, D ;

Wabwire-Mangen, F ;

Lutalo, T ;

Li, XB ;

vanCott, T ;

Quinn, TC .

LANCET, 2001, 357 (9263) :1149-1153

[5]

Investigation of HIV-1 transmission events by phylogenetic methods: requirement for scientific rigour [J].

Hue, S ;

Clewley, JP ;

Cane, PA ;

Pillay, D .

AIDS, 2005, 19 (04) :449-450

[6]

Hué S, 2004, AIDS, V18, P719, DOI [10.1097/01.aids.0000111455.61782.c3, 10.1097/00002030-200403260-00002]

[7]

New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes [J].

Janssen, RS ;

Satten, GA ;

Stramer, SL ;

Rawal, BD ;

O'Brien, TR ;

Weiblen, BJ ;

Hecht, FM ;

Jack, N ;

Cleghorn, FR ;

Kahn, JO ;

Chesney, MA ;

Busch, MP .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (01) :42-48

[8]

Prevalence of transmitted HIV-1 drug resistance and the role of resistance algorithms -: Data from seroconverters in the CASCADE collaboration from 1987 to 2003 [J].

Masquelier, BND ;

Bhaskaran, K ;

Deenan, P ;

Gifford, R ;

Balestre, E ;

Jorgensen, LB ;

Pedersen, C ;

van der Hoek, L ;

Prins, M ;

Balotta, C ;

Longo, B ;

Kücherer, C ;

Poggensee, G ;

Ortiz, M ;

de Mendoza, C ;

Gill, J ;

Fleury, H ;

Porter, K .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 40 (05) :505-511

[9]

Transmission of HIV-1 during primary infection:: relationship to sexual risk and sexually transmitted infections [J].

Pao, D ;

Fisher, M ;

Hué, S ;

Dean, G ;

Murphy, G ;

Cane, PA ;

Sabin, CA ;

Pillay, D .

AIDS, 2005, 19 (01) :85-90

[10]

Detection of acute infections during HIV testing in North Carolina [J].

Pilcher, CD ;

Fiscus, SA ;

Nguyen, TQ ;

Foust, E ;

Wolf, L ;

Williams, D ;

Ashby, R ;

O'Dowd, JO ;

McPherson, JT ;

Stalzer, B ;

Hightow, L ;

Miller, WC ;

Eron, JJ ;

Cohen, MS ;

Leone, PA .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (18) :1873-1883

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