Renal effects of cardiopulmonary bypass in the elderly

被引:14
作者
Dehne, MG
Sablotzki, A
Mühling, J
Dehne, KL
Röhrig, R
Hempelmann, G
机构
[1] Univ Giessen, Dept Anesthesiol & Intens Care Med, D-35385 Giessen, Germany
[2] Univ Halle Wittenberg, Clin Anesthesiol & Intens Care Med, Wittenberg, Germany
[3] UNAIDS, Vienna, Austria
[4] Univ Giessen, Dept Anesthesiol & Intens Care Med, Giessen, Germany
来源
PERFUSION-UK | 2002年 / 17卷 / 03期
关键词
D O I
10.1191/0267659102pf571oa
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiopulmonary bypass is widely believed to be injurious to renal function. The unknown consequences of renal dysfunction with modern techniques of bypass in the elderly caused us to examine creatinine clearance and the excretion of sensitive marker proteins in older adult patients undergoing CABG. Thirty male patients were divided into three groups: group I with an age up to 60 years, group II with an age between 61 and 70 years, inclusive and group III 71 years and over. Serum creatinine and urea, creatinine clearance, and alpha1-microglobulin (alpha1-MG), N-acetyl-beta-D-glucosaminidase (NAG), Tamm-Horsfall protein (TH) and immunoglobulin G (IgG) were all measured daily, pre- and postoperatively. Creatinine clearance remained lower in the older patients without significant differences. Raised excretion rates of alpha1-MG, and IgG were seen after CPB. The increase in alpha1-MG and NAG during the postoperative period revealed tubular damage in all elderly patients. Measurements of alpha1-MG, NAG and IgG represent useful supplements to standard clinical tests for recognizing early and differentiated changes in renal function.
引用
收藏
页码:205 / 209
页数:5
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