The protein information and property explorer: an easy-to-use, rich-client web application for the management and functional analysis of proteomic data

被引:26
作者
Ramos, H. [1 ]
Shannon, P. [1 ]
Aebersold, R. [1 ,2 ,3 ,4 ]
机构
[1] Inst Syst Biol, Seattle, WA 98103 USA
[2] ETH, Inst Mol Syst Biol, Zurich, Switzerland
[3] ETH, Competence Ctr Syst Physiol & Metabol Dis, Zurich, Switzerland
[4] Univ Zurich, Fac Sci, Zurich, Switzerland
基金
美国国家卫生研究院;
关键词
D O I
10.1093/bioinformatics/btn363
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Mass spectrometry experiments in the field of proteomics produce lists containing tens to thousands of identified proteins. With the protein information and property explorer (PIPE), the biologist can acquire functional annotations for these proteins and explore the enrichment of the list, or fraction thereof, with respect to functional classes. These protein lists may be saved for access at a later time or different location. The PIPE is interoperable with the Firegoose and the Gaggle, permitting wide-ranging data exploration and analysis. The PIPE is a rich-client web application which uses AJAX capabilities provided by the Google Web Toolkit, and server-side data storage using Hibernate.
引用
收藏
页码:2110 / 2111
页数:2
相关论文
共 5 条
[1]   The Firegoose: two-way integration of diverse data from different bioinformatics web resources with desktop applications [J].
Bare, J. Christopher ;
Shannon, Paul T. ;
Schmid, Amy K. ;
Baliga, Nitin S. .
BMC BIOINFORMATICS, 2007, 8 (1)
[2]   Using GOstats to test gene lists for GO term association [J].
Falcon, S. ;
Gentleman, R. .
BIOINFORMATICS, 2007, 23 (02) :257-258
[3]   A uniform proteomics MS/MS analysis platform utilizing open XML file formats [J].
Keller, Andrew ;
Eng, Jimmy ;
Zhang, Ning ;
Li, Xiao-jun ;
Aebersold, Ruedi .
MOLECULAR SYSTEMS BIOLOGY, 2005, 1 (1) :2005.0017
[4]   Cytoscape: A software environment for integrated models of biomolecular interaction networks [J].
Shannon, P ;
Markiel, A ;
Ozier, O ;
Baliga, NS ;
Wang, JT ;
Ramage, D ;
Amin, N ;
Schwikowski, B ;
Ideker, T .
GENOME RESEARCH, 2003, 13 (11) :2498-2504
[5]   The Gaggle: An open-source software system for integrating bioinformatics software and data sources [J].
Shannon, Paul T. ;
Reiss, David J. ;
Bonneau, Richard ;
Baliga, Nitin S. .
BMC BIOINFORMATICS, 2006, 7 (1)