Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor

被引：582

作者：

Cosmi, Lorenzo ^{[1
,2
]}

De Palma, Raffaele ^{[5
,6
]}

Santarlasci, Veronica ^{[1
,2
]}

Maggi, Laura ^{[1
,2
]}

Capone, Manuela ^{[1
,2
]}

Frosali, Francesca ^{[1
,2
]}

Rodolico, Gabriella ^{[7
]}

Querci, Valentina ^{[1
,2
]}

Abbate, Gianfranco ^{[5
,6
]}

Angeli, Roberta ^{[1
,2
]}

Berrino, Liberato ^{[7
]}

Fambrini, Massimiliano ^{[3
]}

Caproni, Marzia ^{[8
]}

Tonelli, Francesco ^{[4
]}

Lazzeri, Elena ^{[1
,2
]}

Parronchi, Paola ^{[1
,2
]}

Liotta, Francesco ^{[1
,2
]}

Maggi, Enrico ^{[1
,2
]}

Romagnani, Sergio ^{[1
,2
]}

Annunziato, Francesco ^{[1
,2
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[2] Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy

[3] Univ Florence, Dept Gynecol Perinatol & Human Reprod, I-50134 Florence, Italy

[4] Univ Florence, Dept Pathophysiol, I-50134 Florence, Italy

[5] Univ Naples 2, Dept Clin & Expt Med, I-80131 Naples, Italy

[6] Ctr Reg Competenza Genom, I-80131 Naples, Italy

[7] Univ Naples 2, Sect Pharmacol Sci, I-80131 Naples, Italy

[8] Univ Florence, Dept Dermatol Sci, I-50121 Florence, Italy

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 08期

关键词：

D O I：

10.1084/jem.20080397

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1 beta and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor.

引用

页码：1903 / 1916

页数：14

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