Tailoring cell adhesion using surface-grafted polymer gradient assemblies

被引：150

作者：

Bhat, RR

Chaney, BN

Rowley, J

Liebmann-Vinson, A

Genzer, J ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA

[2] BD Technol, Res Triangle Pk, NC 27709 USA

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 23期

关键词：

D O I：

10.1002/adma.200500858

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surface-grafted polymer assemblies with a gradient in molecular weight (MW) and/or grafting density (sigma) are used to tune protein adsorption, which consequently governs cell adhesion. Increasing the surface coverage of the polymer by increasing the MW and/or sigma results in a decrease in the amount of protein adsorbed, which causes a decrease in the number of cells adhered and a change in cell morphology.

引用

页码：2802 / +

页数：7

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