Management of recurrent and refractory Cushing disease

被引：35

作者：

Aghi, Manish K. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Calif Ctr Pituitary Disorders, San Francisco, CA 94143 USA

来源：

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2008年 / 4卷 / 10期

关键词：

adrenalectomy; Cushing disease; ketoconazole; radiosurgery; transsphenoidal surgery;

D O I：

10.1038/ncpendmet0947

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cushing disease is most frequently caused by pituitary adenomas that secrete adrenocorticotrophic hormone. Transsphenoidal surgery is the treatment of choice in patients with these tumors because of reported remission rates of 69-93%. More challenging for neurosurgeons and endocrinologists, however, is management of the remaining patients whose Cushing disease is refractory to initial transsphenoidal surgery or recurs after initial remission. Here, we review the treatment options and latest surgical, medical, and radiosurgical advances for patients who have persistent or recurrent Cushing disease after transsphenoidal surgery.

引用

页码：560 / 568

页数：9

共 53 条

[1]

AGHI M, CLIN NEUROS IN PRESS

[2] Corticotroph tumor progression after adrenalectomy in Cushing's disease:: A reappraisal of Nelson's syndrome [J].

Assie, Guillaume ;

Bahurel, Helene ;

Coste, Joel ;

Silvera, Stephane ;

Kujas, Michele ;

Dugue, Marie-Annick ;

Karray, Foued ;

Dousset, Bertrand ;

Bertherat, Jerome ;

Legmann, Paul ;

Bertagna, Xavier .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (01) :172-179

[3] Long-term remission rates after pituitary surgery for Cushing's disease: the need for long-term surveillance [J].

Atkinson, AB ;

Kennedy, A ;

Wiggam, MI ;

McCance, DR ;

Sheridan, B .

CLINICAL ENDOCRINOLOGY, 2005, 63 (05) :549-559

[4]

BOSCARO M, 2006, 88 END SOC ANN M 200

[5] Retinoic acid as a novel medical therapy for Cushing's disease in dogs [J].

Castillo, Victor ;

Giacomini, Damiana ;

Paez-Pereda, Marcelo ;

Stalla, Johanna ;

Labeur, Marta ;

Theodoropoulou, Marily ;

Holsboer, Florian ;

Grossman, Ashley B. ;

Stalla, Guenter K. ;

Arzt, Eduardo .

ENDOCRINOLOGY, 2006, 147 (09) :4438-4444

[6] Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease [J].

Castinetti, F. ;

Morange, I. ;

Jaquet, P. ;

Conte-Devolx, B. ;

Brue, T. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (01) :91-99

[7] Gamma knife radiosurgery is a successful adjunctive treatment in Cushing's disease [J].

Castinetti, F. ;

Nagai, M. ;

Dufour, H. ;

Kuhn, J-M ;

Morange, I. ;

Jaquet, P. ;

Conte-Devolx, B. ;

Regis, J. ;

Brue, T. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2007, 156 (01) :91-98

[8] Comparison between the microscope and endoscope in the direct endonasal extended transsphenoidal approach: anatomical study [J].

Catapano, D ;

Sloffer, CA ;

Frank, G ;

Pasquini, E ;

D'Angelo, VA ;

Lanzino, G .

JOURNAL OF NEUROSURGERY, 2006, 104 (03) :419-425

[9] Transsphenoidal pituitary surgery in Cushing's disease: can we predict outcome? [J].

Chee, GH ;

Mathias, DB ;

James, RA ;

Kendall-Taylor, P .

CLINICAL ENDOCRINOLOGY, 2001, 54 (05) :617-626

[10] Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression test [J].

Chen, JCT ;

Amar, AP ;

Choi, S ;

Singer, P ;

Couldwell, WT ;

Weiss, MH .

JOURNAL OF NEUROSURGERY, 2003, 98 (05) :967-973

← 1 2 3 4 5 6 →