Anti-HIV-1 activities of 1,3-dioxolane guanine and 2,6-diaminopurine dioxolane

被引：15

作者：

Gu, ZX

Wainberg, MA

Nguyen-Ba, P

L'Heureux, L

de Muys, JM

Rando, RF

机构：

[1] BioChem Therapeut Inc, Laval, PQ H7V 4A7, Canada

[2] McGill Univ, Jewish Gen Hosp, AIDS Ctr, Montreal, PQ H3T 1E2, Canada

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041594

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC(50)s for DXG were 0.032 mu M in CBMCs and 0.05 mu M in MT-4 cells, which were generally equipotent as 3TC. 3TC-resistant, but not AZT-resistant, HIV-1 had minimum diminished sensitivity to the compounds. Both DXG and DAPD were non-toxic to cells up to 500 mu M.

引用

页码：891 / 892

页数：2

共 2 条

[1] Pharmacokinetics of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, in woodchucks (Marmota monax)
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