Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic

被引：39

作者：

Chu, CM

Yeh, CT

Chiu, CT

Sheen, IS

Liaw, YF

机构：

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1996年 / 34卷 / 07期

关键词：

D O I：

10.1128/JCM.34.7.1815-1818.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By using an amplification-create restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis, The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.

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页码：1815 / 1818

页数：4

相关论文

共 26 条

[1] VARIATIONS OF HEPATITIS-B VIRUS PRECORE/CORE GENE SEQUENCE IN ACUTE AND FULMINANT HEPATITIS-B [J].

AYE, TT ;

UCHIDA, T ;

BECKER, SO ;

HIRASHIMA, M ;

SHIKATA, T ;

KOMINE, F ;

MORIYAMA, M ;

ARAKAWA, Y ;

MIMA, S ;

MIZOKAMI, M ;

LAU, JYN .

DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (06) :1281-1287

[2]

BONINO F, 1994, VIRAL HEPATITIS LIVE, P256

[3] WILD-TYPE AND E-ANTIGEN-MINUS HEPATITIS-B VIRUSES AND COURSE OF CHRONIC HEPATITIS [J].

BRUNETTO, MR ;

GIARIN, MM ;

OLIVERI, F ;

CHIABERGE, E ;

BALDI, M ;

ALFARANO, A ;

SERRA, A ;

SARACCO, G ;

VERME, G ;

WILL, H ;

BONINO, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4186-4190

[4]

CARMAN WF, 1989, LANCET, V2, P588

[5]

CARMAN WF, 1991, VIRAL HEPATITIS AND LIVER DISEASE, P216

[6]

CARMAN WF, 1991, HEPATOLOGY, V14, P319

[7] THE ETIOLOGY OF ACUTE HEPATITIS SUPERIMPOSED UPON PREVIOUSLY UNRECOGNIZED ASYMPTOMATIC HBSAG-CARRIERS [J].

CHU, CM ;

LIAW, YF ;

PAO, CC ;

HUANG, MJ .

HEPATOLOGY, 1989, 9 (03) :452-456

[8] THE ROLE OF HEPATITIS-C VIRUS IN FULMINANT VIRAL-HEPATITIS IN AN AREA WITH ENDEMIC HEPATITIS-A AND HEPATITIS-B [J].

CHU, CM ;

SHEEN, IS ;

LIAW, YF .

GASTROENTEROLOGY, 1994, 107 (01) :189-195

[9] THE INCIDENCE OF FULMINANT HEPATIC-FAILURE IN ACUTE VIRAL-HEPATITIS IN TAIWAN - INCREASED RISK IN PATIENTS WITH PREEXISTING HBSAG CARRIER STATE [J].

CHU, CM ;

LIAW, YF .

INFECTION, 1990, 18 (04) :200-203

[10] NATURAL-HISTORY OF CHRONIC HEPATITIS-B VIRUS-INFECTION IN TAIWAN - STUDIES OF HEPATITIS-B VIRUS-DNA IN SERUM [J].

CHU, CM ;

KARAYIANNIS, P ;

FOWLER, MJF ;

MONJARDINO, J ;

LIAW, YF ;

THOMAS, HC .

HEPATOLOGY, 1985, 5 (03) :431-434