Essential thrombacythemia with BCR/ABL rearrangement

被引:27
作者
Kwong, YL
Chiu, EKW
Liang, RHS
Chan, V
Chan, TK
机构
[1] University Department of Medicine, Queen Mary Hospital, Hong Kong, Pokfulam Road
[2] University Department of Medicine, Professorial Block, Queen Mary Hospital, Hong Kong, Pokfulam Road
关键词
D O I
10.1016/0165-4608(94)00108-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement.
引用
收藏
页码:74 / 76
页数:3
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