Epigenetic variation in Arabidopsis disease resistance

被引：227

作者：

Stokes, TL ^{[1
]}

Kunkel, BN ^{[1
]}

Richards, EJ ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

GENES & DEVELOPMENT | 2002年 / 16卷 / 02期

关键词：

epigenetics; cytosine methylation; resistance genes; bal; DDM1; Arabidopsis;

D O I：

10.1101/gad.952102

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Plant pathogen resistance is mediated by a large repertoire of resistance (R) genes, which are often clustered in the genome and show a high degree of genetic variation. Here, we show that an Arabidopsis thaliana R-gene cluster is also subject to epigenetic variation. We describe a heritable but metastable epigenetic variant bat that overexpresses the R-like gene At4g16890 from a gene cluster on Chromosome 4. The bat variant and Arabidopsis transgenics overexpressing the At4g16890 gene are dwarfed and constitutively activate the salicylic acid (SA)-dependent defense response pathway. Overexpression of a related R-like gene also occurs in the ssi1 (suppressor of SA insensitivity 1) background, suggesting that ssi1 is mechanistically related to bal.

引用

页码：171 / 182

页数：12

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