Value of magnetic resonance imaging in assessing efficacy in clinical trials of multiple sclerosis therapies

被引:13
作者
Erickson, BJ [1 ]
Noseworthy, JH [1 ]
机构
[1] MAYO CLIN, DEPT NEUROL, ROCHESTER, MN USA
关键词
D O I
10.4065/72.11.1080
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Magnetic resonance imaging (MRI) has become an important technique for monitoring the effectiveness of putative treatments for multiple sclerosis (MS) because of its high sensitivity, objectivity, and noninvasive nature, Its importance as a surrogate measure of disease, however, is an issue that is more difficult to validate than might seem to be the case, In this review, we describe the role of MRI in the assessment of putative therapies for MS, New magnetic resonance techniques and methods of image analyses aimed at better demonstrating the nature and extent of disease are discussed, and the role of MRI in published MS therapeutic trials is examined, MRI is a frequently used secondary outcome measure for putative treatment strategies for MS, Although it is sensitive to changes in the inflammatory component of the MS disease process, poor correlation has been noted between MRI findings and long-term patient outcome, There is a widespread expectation that new magnetic resonance techniques-such as fluid-attenuated inversion recovery, magnetization transfer imaging, and magnetic resonance spectroscopy-will ultimately be useful for characterization of pathologic changes within the MS lesion and more generally of the MS disease process, Whether magnetic resonance changes seen in experimental therapies predict the long-term clinical course of the disease remains to be determined.
引用
收藏
页码:1080 / 1089
页数:10
相关论文
共 96 条
  • [1] Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis
    Andersen, O
    Lycke, J
    Tollesson, PO
    Svenningsson, A
    Runmarker, B
    Linde, AS
    Astrom, M
    Gjorstrup, P
    Ekholm, S
    [J]. NEUROLOGY, 1996, 47 (04) : 895 - 900
  • [2] INVIVO DETERMINATION OF MULTIEXPONENTIAL T2 RELAXATION IN THE BRAIN OF PATIENTS WITH MULTIPLE-SCLEROSIS
    ARMSPACH, JP
    GOUNOT, D
    RUMBACH, L
    CHAMBRON, J
    [J]. MAGNETIC RESONANCE IMAGING, 1991, 9 (01) : 107 - 113
  • [3] USE OF PROTON MAGNETIC-RESONANCE SPECTROSCOPY FOR MONITORING DISEASE PROGRESSION IN MULTIPLE-SCLEROSIS
    ARNOLD, DL
    RIESS, GT
    MATTHEWS, PM
    FRANCIS, GS
    COLLINS, DL
    WOLFSON, C
    ANTEL, JP
    [J]. ANNALS OF NEUROLOGY, 1994, 36 (01) : 76 - 82
  • [4] RELAPSING-REMITTING MULTIPLE-SCLEROSIS - SEQUENTIAL ENHANCED MR IMAGING VS CLINICAL FINDINGS IN DETERMINING DISEASE-ACTIVITY
    BARKHOF, F
    SCHELTENS, P
    FREQUIN, STFM
    NAUTA, JJP
    TAS, MW
    VALK, J
    HOMMES, OR
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 1992, 159 (05) : 1041 - 1047
  • [5] SERIAL STUDY OF GADOLINIUM-DTPA MRI ENHANCEMENT IN MULTIPLE-SCLEROSIS
    BASTIANELLO, S
    POZZILLI, C
    BERNARDI, S
    BOZZAO, L
    FANTOZZI, LM
    BUTTINELLI, C
    FIESCHI, C
    [J]. NEUROLOGY, 1990, 40 (04) : 591 - 595
  • [6] A CONTROLLED TRIAL OF MITOXANTRONE IN MULTIPLE-SCLEROSIS - SERIAL MRI EVALUATION AT ONE-YEAR
    BASTIANELLO, S
    POZZILLI, C
    DANDREA, F
    MILLEFIORINI, E
    TROJANO, M
    MORINO, S
    GASPERINI, C
    BOZZAO, A
    GALLUCCI, M
    ANDREULA, C
    BOZZAO, L
    GAMBI, D
    PRENCIPE, M
    [J]. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1994, 21 (03) : 266 - 270
  • [7] CHRISTIANSEN P, 1993, ACTA NEUROL SCAND, V87, P195
  • [8] COHEN JA, 1995, NEUROLOGY, V45, pA418
  • [9] COOK SD, 1995, NEUROLOGY, V45, pA417
  • [10] SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE MULTIPLE-SCLEROSIS LESIONS
    DAVIE, CA
    HAWKINS, CP
    BARKER, GJ
    BRENNAN, A
    TOFTS, PS
    MILLER, DH
    MCDONALD, WI
    [J]. BRAIN, 1994, 117 : 49 - 58