Novel Diels-Alder reaction of 4-nitro-1(2H)-isoquinolones

被引：8

作者：

Fujita, R ^{[1
]}

Wakayanagi, S ^{[1
]}

Wakamatsu, H ^{[1
]}

Matsuzaki, H ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 02期

关键词：

4-nitro-1(2H)-isoquinolone; 5(6H)-phenanthridone; Diels-Alder reaction; inhibitor; regioselectivity; calculation;

D O I：

10.1248/cpb.54.209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel Diels-Alder (DA) reaction with 4-nitro-1(2H)-isoquinolones acting as the dienophile afforded 5(6H)-phenanthridone derivatives. The DA reaction of 4-nitro-1(2H)-isoquinolone with 1-methoxy-1,3-butadiene gave biologically active 5(6H)-phenanthridone possessing in a high yield. Regioselectivity of 4-nitro-1(2H)-isoquinolones with 1-methoxy-3-silyloxy-1,3-butadiene was calculated using molecular orbital (MO) calculations.

引用

页码：209 / 212

页数：4

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