Are there pancreatic progenitor cells from which new islets form after birth?

被引：47

作者：

Bonner-Weir, S

Sharma, A

机构：

[1] Joslin Diabet Ctr, Sect Islet Transplantat & Cell Biol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2006年 / 2卷 / 05期

关键词：

D O I：

10.1038/ncpendmet0186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although pancreatic islet transplantation can restore normal β-cell function to patients with diabetes, success is limited by tissue availability. An alternative strategy is to stimulate development of the patients' own β cells; however, the postnatal origin of new β cells remains controversial. This Viewpoint proposes that progenitor cells could exist in the pancreatic ducts.

引用

收藏

页码：240 / 241

页数：2

相关论文

共 10 条

[1] Perspective:: Postnatal pancreatic β cell growth [J].

Bonner-Weir, S .

ENDOCRINOLOGY, 2000, 141 (06) :1926-1929

[2] The pancreatic ductal epithelium serves as a potential pool of progenitor cells [J].

Bonner-Weir, S ;

Toschi, E ;

Inada, A ;

Reitz, P ;

Fonseca, SY ;

Aye, T ;

Sharma, A .

PEDIATRIC DIABETES, 2004, 5 :16-22

[3] In vitro cultivation of human islets from expanded ductal tissue [J].

Bonner-Weir, S ;

Taneja, M ;

Weir, GC ;

Tatarkiewicz, K ;

Song, KH ;

Sharma, A ;

O'Neil, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7999-8004

[4] New sources of pancreatic β-cells [J].

Bonner-Weir, S ;

Weir, GC .

NATURE BIOTECHNOLOGY, 2005, 23 (07) :857-861

[5] Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation [J].

Dor, Y ;

Brown, J ;

Martinez, OI ;

Melton, DA .

NATURE, 2004, 429 (6987) :41-46

[6] DYNAMICS OF BETA-CELL MASS IN THE GROWING RAT PANCREAS - ESTIMATION WITH A SIMPLE MATHEMATICAL-MODEL [J].

FINEGOOD, DT ;

SCAGLIA, L ;

BONNERWEIR, S .

DIABETES, 1995, 44 (03) :249-256

[7] Linear correlation between β-cell mass and body weight throughout the lifespan in Lewis rats -: Role of β-cell hyperplasia and hypertrophy [J].

Montanya, E ;

Nacher, V ;

Biarnés, M ;

Soler, J .

DIABETES, 2000, 49 (08) :1341-1346

[8] The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration [J].

Sharma, A ;

Zangen, DH ;

Reitz, P ;

Taneja, M ;

Lissauer, ME ;

Miller, CP ;

Weir, GC ;

Habener, JF ;

Bonner-Weir, S .

DIABETES, 1999, 48 (03) :507-513

[9] Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets -: Effects of the ob gene and compensatory growth of the implantation organ [J].

Tyrberg, B ;

Ustinov, J ;

Otonkoski, T ;

Andersson, A .

DIABETES, 2001, 50 (02) :301-307

[10] Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats [J].

Xu, G ;

Stoffers, DA ;

Habener, JF ;

Bonner-Weir, S .

DIABETES, 1999, 48 (12) :2270-2276