Deoxyribozyme-based logic gates

被引：385

作者：

Stojanovic, MN

Mitchell, TE

Stefanovic, D

机构：

[1] Columbia Univ, Dept Med, Div Clin Pharmacol & Exptl Therapeut, New York, NY 10032 USA

[2] Univ New Mexico, Dept Comp Sci, Albuquerque, NM 87131 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 14期

关键词：

D O I：

10.1021/ja016756v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.

引用

页码：3555 / 3561

页数：7

共 58 条

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