Drug efflux and parC mutations are involved in fluoroquinolone resistance in viridans group streptococci

被引：26

作者：

Ferrándiz, MJ

Oteo, J

Aracil, B

Gómez-Garcés, JL

de la Campa, AG

机构：

[1] Inst Salud Carlos III, Ctr Nacl Biol Fundamental, CSIC, Unidad Genet Bacteriana, Madrid 28220, Spain

[2] Hosp Mostoles, Microbiol Serv, Madrid 28935, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期

关键词：

D O I：

10.1128/AAC.43.10.2520

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nine ciprofloxacin-resistant viridans group streptococci isolated from asymptomatic carriers were analyzed. Identification to the species level by using three different commercial systems and a PCR-based approach was inconsistent. The nucleotide sequences of fragments of the parC, parE, gyrA, and gyrB genes showed considerable intra- and interspecies variations, and these variations mainly involved silent mutations. Three isolates had changes in Ser-79 of ParC (to Phe or Tyr). Phenotypic characterization indicated that eight of the nine isolates had a putative efflux mechanism that would confer low-level resistance to ciprofloxacin.

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页码：2520 / 2523

页数：4

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