Angiopellosis as an Alternative Mechanism of Cell Extravasation

被引：44

作者：

Allen, Tyler A. ^{[1
,2
,3
,4
]}

Gracieux, David ^{[5
]}

Talib, Maliha ^{[5
]}

Tokarz, Debra A. ^{[1
,2
]}

Hensley, M. Taylor ^{[1
,2
]}

Cores, Jhon ^{[1
,2
,3
,4
]}

Vandergriff, Adam ^{[1
,2
,3
,4
]}

Tang, Junnan ^{[1
,2
,3
,4
,6
]}

de Andrade, James B. M. ^{[1
,2
]}

Dinh, Phuong-Uyen ^{[1
,2
]}

Yoder, Jeffrey A. ^{[1
,2
]}

Cheng, Ke ^{[1
,2
,3
,4
,7
,8
]}

机构：

[1] North Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA

[2] North Carolina State Univ, Coll Vet Med, Comparat Med Inst, Raleigh, NC USA

[3] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC USA

[4] North Carolina State Univ, Raleigh, NC USA

[5] North Carolina State Univ, Dept Biochem, Raleigh, NC USA

[6] Zhengzhou Univ, Affiliated Hosp 1, Dept Cardiol, Zhengzhou, Henan, Peoples R China

[7] Univ N Carolina, Mol Pharmaceut Div, Chapel Hill, NC USA

[8] Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou, Jiangshu, Peoples R China

来源：

STEM CELLS | 2017年 / 35卷 / 01期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis; ZEBRAFISH; BLOOD; TRAFFICKING; INTEGRIN;

D O I：

10.1002/stem.2451

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stem cells possess the ability to home in and travel to damaged tissue when injected intravenously. For the cells to exert their therapeutic effect, they must cross the blood vessel wall and enter the surrounding tissues. The mechanism of extravasation injected stem cells employ for exit has yet to be characterized. Using intravital microscopy and a transgenic zebrafish line Tg(fli1a:egpf) with GFP-expressing vasculature, we documented the detailed extravasation processes in vivo for injected stem cells in comparison to white blood cells (WBCs). While WBCs left the blood vessels by the standard diapedesis process, injected cardiac and mesenchymal stem cells underwent a distinct method of extravasation that was markedly different from diapedesis. Here, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity. We termed this process Angio-pello-sis, which represents an alternative mechanism of cell extravasation to the prevailing theory of diapedesis.

引用

页码：170 / 180

页数：11

共 33 条

[1]

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].